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KMID : 0438520110180010042
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Journal of the Korean Society of Neonatology
2011 Volume.18 No. 1 p.42 ~ p.48
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Association between Tumor Necrosis Factor-α Gene Polymorphism and Bronchopulmonary Dysplasia in Preterm Infants
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Jo Heui-Seung
Jang Yoon-Hwan
Kim Han-Suk
Kim Beyong-Il
Choi Jung-Hwan
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Abstract
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Purpose: Several factors including prolonged inflammatory response are thought to contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The clinical findings can be explained by an increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α). We investigated the relationship between susceptibility to BPD and TNF-α promoter polymorphisms to identify genetic factors of the disease.
Methods: Thirty-eight preterm infants who had developed BPD and 55 controlled infants with a birth weight <1,500 g were analyzed for TNF-α genotypes. The alleles of five promoter sites (-1031/-863/-857/-308/-238) of TNF-α gene were determined using Taqman®-based allelic discrimination assays.
Results: Gestational age (27+5±2+0 wk vs. 29+2±1+4 wk, P<0.0001) and birth weight (990±270 g vs. 1,220±230 g, P<0.0001) were lower in the BPD group compared to the control group. The incidence of respiratory distress syndrome (71.1% vs. 49.1%, P=0.035) and patent ductus arteriosus (71.1% vs. 50.9%, P=0.052) was higher in the BPD group compared to the control group. The frequencies of the alleles and genotypes of five promoter sites (-1031/-863/-857/-308/-238) of TNF-α gene did not show differences between the BPD group and the control group.
Conclusion: TNF-α promoter polymorphisms are not associated with susceptibility to BPD in Korean preterm infants.
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KEYWORD
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Tumor necrosis factor-α, Genetic polymorphism, Bronchopulmonary dysplasia, Premature infant
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